Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

KRASG12V and BRAFV600E are oncogenic mutations that activate ERK signalling. Here, the authors use single cell analysis in intestinal organoids and show that BRAFV600E activates ERK in all intestinal cell types, while KRASG12V induces ERK activation in only a subset of cells, depending on cell diffe...

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Bibliographic Details
Main Authors: Raphael Brandt, Thomas Sell, Mareen Lüthen, Florian Uhlitz, Bertram Klinger, Pamela Riemer, Claudia Giesecke-Thiel, Silvia Schulze, Ismail Amr El-Shimy, Desiree Kunkel, Beatrix Fauler, Thorsten Mielke, Norbert Mages, Bernhard G. Herrmann, Christine Sers, Nils Blüthgen, Markus Morkel
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10954-y

Internet

https://doi.org/10.1038/s41467-019-10954-y

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