Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)

Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)

Abstract Homozygous mutations in the lysosomal glucocerebrosidase gene, GBA1, cause Gaucher’s disease (GD), while heterozygous mutations in GBA1 are a strong risk factor for Parkinson’s disease (PD), whose pathological hallmark is intraneuronal α-synuclein (asyn) aggregates. We previously reported t...

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Bibliographic Details
Main Authors: Etsuro Nakanishi, Norihito Uemura, Hisako Akiyama, Masato Kinoshita, Sawamura Masanori, Yosuke Taruno, Hodaka Yamakado, Shu-ichi Matsuzawa, Shunichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Molecular Brain
Subjects:
GBA1
GBA2
Gaucher’s disease
Parkinson’s disease
α-Synuclein
Glucocerebrosidase
Online Access:https://doi.org/10.1186/s13041-021-00790-x

Internet

https://doi.org/10.1186/s13041-021-00790-x

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