Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)
Abstract Homozygous mutations in the lysosomal glucocerebrosidase gene, GBA1, cause Gaucher’s disease (GD), while heterozygous mutations in GBA1 are a strong risk factor for Parkinson’s disease (PD), whose pathological hallmark is intraneuronal α-synuclein (asyn) aggregates. We previously reported t...
Main Authors: | Etsuro Nakanishi, Norihito Uemura, Hisako Akiyama, Masato Kinoshita, Sawamura Masanori, Yosuke Taruno, Hodaka Yamakado, Shu-ichi Matsuzawa, Shunichi Takeda, Yoshio Hirabayashi, Ryosuke Takahashi |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-05-01
|
Series: | Molecular Brain |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13041-021-00790-x |
Similar Items
-
The GBA p.G85E mutation in Korean patients with non-neuronopathic Gaucher disease: founder and neuroprotective effects
by: Yoo-Mi Kim, et al.
Published: (2020-11-01) -
A novel mutation deep within intron 7 of the GBA gene causes Gaucher disease
by: Anna Malekkou, et al.
Published: (2020-03-01) -
Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein
by: Uemura, Norihito
Published: (2015) -
Small Molecule Chaperones for the Treatment of Gaucher Disease and GBA1-Associated Parkinson Disease
by: Tae-Un Han, et al.
Published: (2020-05-01) -
Gaucher disease: Biochemical and molecular findings in 141 patients diagnosed in Greece
by: Evangelia Dimitriou, et al.
Published: (2020-09-01)