Maternal High Fat Diet and in-Utero Metformin Exposure Significantly Impact upon the Fetal Renal Proteome of Male Mice

Maternal High Fat Diet and in-Utero Metformin Exposure Significantly Impact upon the Fetal Renal Proteome of Male Mice

There is accumulating evidence for fetal programming of later kidney disease by maternal obesity or associated conditions. We performed a hypothesis-generating study to identify potentially underlying mechanisms. Female mice were randomly split in two groups and fed either a standard diet (SD) or hi...

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Bibliographic Details
Main Authors: Eva Nüsken, Eva-Maria Turnwald, Gregor Fink, Jenny Voggel, Christopher Yosy, Tobias Kretschmer, Marion Handwerk, Maria Wohlfarth, Lutz T. Weber, Eva Hucklenbruch-Rother, Jörg Dötsch, Kai-Dietrich Nüsken, Sarah Appel
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Journal of Clinical Medicine
Subjects:
fetal development
high fat diet
intrauterine programming
kidney
metformin
maternal obesity
Online Access:https://www.mdpi.com/2077-0383/8/5/663

Internet

https://www.mdpi.com/2077-0383/8/5/663

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