Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease

Human LRRK2 (Leucine-Rich Repeat Kinase 2) has been associated with both familial and idiopathic Parkinson’s disease (PD). Although several LRRK2 mediated pathways and interaction partners have been identified, the cellular functions of LRRK2 and LRRK2 mediated progression of PD are still only parti...

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Bibliographic Details
Main Authors: Katharina E. Rosenbusch, Arjan Kortholt
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Parkinson's Disease
Online Access:http://dx.doi.org/10.1155/2016/7351985