Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques.

Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques.

Toll-like receptor (TLR) ligands are being considered as adjuvants for the induction of antigen-specific immune responses, as in the design of vaccines. Polyriboinosinic-polyribocytoidylic acid (poly I:C), a synthetic double-stranded RNA (dsRNA), is recognized by TLR3 and other intracellular recepto...

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Bibliographic Details
Main Authors: Christiane Stahl-Hennig, Martin Eisenblätter, Edith Jasny, Tamara Rzehak, Klara Tenner-Racz, Christine Trumpfheller, Andres M Salazar, Klaus Uberla, Karen Nieto, Jürgen Kleinschmidt, Reiner Schulte, Lutz Gissmann, Martin Müller, Anna Sacher, Paul Racz, Ralph M Steinman, Mariagrazia Uguccioni, Ralf Ignatius
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2660151?pdf=render

Internet

http://europepmc.org/articles/PMC2660151?pdf=render

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