Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region.

Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region.

The membrane proximal external region (MPER) of HIV-1 gp41 has several features that make it an attractive antibody-based vaccine target, but eliciting an effective gp41 MPER-specific protective antibody response remains elusive. One fundamental issue is whether the failure to make gp41 MPER-specifi...

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Bibliographic Details
Main Authors: Laurent Verkoczy, M Anthony Moody, T Matt Holl, Hilary Bouton-Verville, Richard M Scearce, Jennifer Hutchinson, S Munir Alam, Garnett Kelsoe, Barton F Haynes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2751816?pdf=render

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http://europepmc.org/articles/PMC2751816?pdf=render

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