Novel Non-Coding Transcript in NR4A3 Locus, LncNR4A3, Regulates RNA Processing Machinery Proteins and NR4A3 Expression

Novel Non-Coding Transcript in NR4A3 Locus, LncNR4A3, Regulates RNA Processing Machinery Proteins and NR4A3 Expression

NR4A3 is a key tumor suppressor in myeloid malignancy, mice lacking both NR4A1 and family member NR4A3 rapidly develop lethal acute myeloid leukemia (AML). We identified a long non-coding transcript in the NR4A3 locus and pursued the characterization of this anonymous transcript and the study of its...

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Bibliographic Details
Main Authors: Ada Congrains, Fernanda Soares Niemann, Adriana Da Silva Santos Duarte, Karla Priscila Vieira Ferro, Sara Teresinha Olalla-Saad
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Oncology
Subjects:
NR4A3
RNA processing
long non-coding RNA
myeloid malignancy
acute myeloid leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.569668/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.569668/full

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