Conjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic properties.

Conjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic properties.

Benzyl-o-vanillin and benzimidazole nucleus serve as important pharmacophore in drug discovery. The benzyl vanillin (2-(benzyloxy)-3-methoxybenzaldehyde) compound shows anti-proliferative activity in HL60 leukemia cancer cells and can effect cell cycle progression at G2/M phase. Its apoptosis activi...

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Bibliographic Details
Main Authors: Zena A Al-Mudaris, Aman S A Majid, Dan Ji, Ban A Al-Mudarris, Shih-Hsun Chen, Po-Huang Liang, Hasnah Osman, Shah Kamal Khan Jamal Din, Amin M S Abdul Majid
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3829952?pdf=render

Internet

http://europepmc.org/articles/PMC3829952?pdf=render

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