Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer.
The serine/threonine kinase Aurora-A (Aur-A) is a proto-oncoprotein overexpressed in a wide range of human cancers. Overexpression of Aur-A is thought to be caused by gene amplification or mRNA overexpression. However, recent evidence revealed that the discrepancies between amplification of Aur-A an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-09-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC1976594?pdf=render |