Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury

Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury

Abstract Background Spinal cord injury (SCI) is a catastrophic trauma accompanied by intralesional bleeding and neuroinflammation. Recently, there is increasing interest in tranexamic acid (TXA), an anti-fibrinolytic drug, which can reduce the bleeding volume after physical trauma. However, the effi...

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Bibliographic Details
Main Authors: Shingo Yoshizaki, Ken Kijima, Masamitsu Hara, Takeyuki Saito, Tetsuya Tamaru, Masatake Tanaka, Dai-jiro Konno, Yasuharu Nakashima, Seiji Okada
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Neuroinflammation
Subjects:
Spinal cord injury
Tranexamic acid
Heme
Toll-like receptor 4
Demyelination
Hyperfibrinolysis
Online Access:http://link.springer.com/article/10.1186/s12974-019-1536-y

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http://link.springer.com/article/10.1186/s12974-019-1536-y

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