Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration

Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration

Abstract Background Experimental autoimmune encephalomyelitis (EAE) is the most common animal model of multiple sclerosis (MS), a neuroinflammatory and demyelinating disease characterized by multifocal perivascular infiltrates of immune cells. Although EAE is predominantly considered a T helper 1-dr...

Full description

Bibliographic Details
Main Authors: Giovanni Ferrara, Andrea Benzi, Laura Sturla, Daniela Marubbi, Davide Frumento, Sonia Spinelli, Elena Abbotto, Federico Ivaldi, Maria von Holtey, Maximilien Murone, Alessio Nencioni, Antonio Uccelli, Santina Bruzzone
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Neuroinflammation
Subjects:
SIRT6
EAE
Dendritic cells
Migration
Clinically isolated syndrome
MS
Online Access:http://link.springer.com/article/10.1186/s12974-020-01906-1

Internet

http://link.springer.com/article/10.1186/s12974-020-01906-1

Similar Items