Elevated expression of mcl-1 inhibits apoptosis and predicts poor prognosis in patients with surgically resected non-small cell lung cancer

Elevated expression of mcl-1 inhibits apoptosis and predicts poor prognosis in patients with surgically resected non-small cell lung cancer

Abstract Background Mcl-1, an anti-apoptotic member of bcl-2 family, together with cleaved poly (ADC-ribose) polymerase (c-PARP) can serve as a marker of cell apoptosis. Previously we reported that treatment of Mnk inhibitor CGP57380 resulted in decreased Mcl-1 expression while increased c-PARP expr...

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Bibliographic Details
Main Authors: Qiuyuan Wen, Yuting Zhan, Hongmei Zheng, Hongjing Zang, Jiadi Luo, Yuting Zhang, Weiyuan Wang, Juan Feng, Junmi Lu, Lingjiao Chen, Songqing Fan
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Diagnostic Pathology
Subjects:
Non-small cell lung cancer (NSCLC)
Mcl-1
Ki-67
C-PARP
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13000-019-0884-3

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http://link.springer.com/article/10.1186/s13000-019-0884-3

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