Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole

Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole

2-Cyanobenzothiazoles (CBTs) are useful building blocks for: 1) luciferin derivatives for bioluminescent imaging; and 2) handles for bioorthogonal ligations. A particularly versatile CBT is 6-amino-2-cyanobenzothiazole (ACBT), which has an amine handle for straight-forward derivatisation. Here we pr...

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Bibliographic Details
Main Authors: Jacob R. Hauser, Hester A. Beard, Mary E. Bayana, Katherine E. Jolley, Stuart L. Warriner, Robin S. Bon
Format: Article
Language:English
Published: Beilstein-Institut 2016-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
ACBT
cyanation
2-cyanobenzothiazoles
DABCO
luciferins
organocatalysis
Online Access:https://doi.org/10.3762/bjoc.12.189

Internet

https://doi.org/10.3762/bjoc.12.189

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