A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device

A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device

Three-dimensional (3D) models with cells arranged in clusters or spheroids have emerged as valuable tools to improve physiological relevance in drug screening. One of the challenges with cells cultured in 3D, especially for high-throughput applications, is to quickly and non-invasively assess the ce...

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Bibliographic Details
Main Authors: Jonas Christoffersson, Florian Meier, Henning Kempf, Kristin Schwanke, Michelle Coffee, Mario Beilmann, Robert Zweigerdt, Carl-Fredrik Mandenius
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Bioengineering
Subjects:
3D cell culture
microfluidics
organ-on-a-chip
cardiac spheroids
cardiomyocytes
induced pluripotent stem cells (iPSCs)
drug screening
Online Access:http://www.mdpi.com/2306-5354/5/2/36

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http://www.mdpi.com/2306-5354/5/2/36

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