H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice

H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice

Low pathogenic avian influenza (LPAI) H7N9 viruses have recently evolved to gain a polybasic cleavage site in the hemagglutinin (HA) protein, resulting in variants with increased lethality in poultry that meet the criteria for highly pathogenic avian influenza (HPAI) viruses. Both LPAI and HPAI vari...

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Bibliographic Details
Main Authors: Mable Chan, Anders Leung, Tamiko Hisanaga, Brad Pickering, Bryan D. Griffin, Robert Vendramelli, Nikesh Tailor, Gary Wong, Yuhai Bi, Shawn Babiuk, Yohannes Berhane, Darwyn Kobasa
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Viruses
Subjects:
hpai
h7n9
influenza virus
mammalian adaptation
mice
polybasic ha
Online Access:https://www.mdpi.com/1999-4915/12/1/65

Internet

https://www.mdpi.com/1999-4915/12/1/65

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