Swainsonine Triggers Paraptosis via ER Stress and MAPK Signaling Pathway in Rat Primary Renal Tubular Epithelial Cells

Swainsonine Triggers Paraptosis via ER Stress and MAPK Signaling Pathway in Rat Primary Renal Tubular Epithelial Cells

Swainsonine (SW), an indolizidine alkaloid extracted from locoweeds, was shown toxic effects in multiple studies, but the underlying action mechanism remains unclear. SW is known to cause autophagy and apoptosis, but there has been no report on paraptosis mediated cell death. Here, we showed that SW...

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Bibliographic Details
Main Authors: Shuai Wang, Yazhou Guo, Chen Yang, Ruijie Huang, Yuting Wen, Chunyan Zhang, Chenchen Wu, Baoyu Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
swainsonine
paraptosis
vacuolation
er stress
MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.715285/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.715285/full

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