An examination of the relationship between hotspots and recombination associated with chromosome 21 nondisjunction.

An examination of the relationship between hotspots and recombination associated with chromosome 21 nondisjunction.

Trisomy 21, resulting in Down Syndrome (DS), is the most common autosomal trisomy among live-born infants and is caused mainly by nondisjunction of chromosome 21 within oocytes. Risk factors for nondisjunction depend on the parental origin and type of meiotic error. For errors in the oocyte, increas...

Full description

Bibliographic Details
Main Authors: Tiffany Renee Oliver, Candace D Middlebrooks, Stuart W Tinker, Emily Graves Allen, Lora J H Bean, Ferdouse Begum, Eleanor Feingold, Reshmi Chowdhury, Vivian Cheung, Stephanie L Sherman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4057233?pdf=render

Internet

http://europepmc.org/articles/PMC4057233?pdf=render

Similar Items