Uric Acid Has Direct Proinflammatory Effects on Human Macrophages by Increasing Proinflammatory Mediators and Bacterial Phagocytosis Probably via URAT1

Uric Acid Has Direct Proinflammatory Effects on Human Macrophages by Increasing Proinflammatory Mediators and Bacterial Phagocytosis Probably via URAT1

The relationship of uric acid with macrophages has not been fully elucidated. We investigated the effect of uric acid on the proinflammatory ability of human macrophages and then examined the possible molecular mechanism involved. Primary human monocytes were differentiated into macrophages for subs...

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Bibliographic Details
Main Authors: Camilo P. Martínez-Reyes, Aarón N. Manjarrez-Reyna, Lucia A. Méndez-García, José A. Aguayo-Guerrero, Beatriz Aguirre-Sierra, Rafael Villalobos-Molina, Yolanda López-Vidal, Karen Bobadilla, Galileo Escobedo
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
macrophage
uric acid
TNF-alpha
TLR4
phagocytosis
probenecid
Online Access:https://www.mdpi.com/2218-273X/10/4/576

Internet

https://www.mdpi.com/2218-273X/10/4/576

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