Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis

Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis

Abstract Background Upregulation of estrogen receptor beta (ERβ) in breast cancer cells is associated with epithelial maintenance, decreased proliferation and invasion, and a reduction in the expression of the receptor has been observed in invasive breast tumors. However, proof of an association bet...

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Bibliographic Details
Main Authors: Igor Bado, Fotis Nikolos, Gayani Rajapaksa, Wanfu Wu, Jessica Castaneda, Savitri Krishnamurthy, Paul Webb, Jan-Åke Gustafsson, Christoforos Thomas
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Breast Cancer Research
Subjects:
Estrogen receptor beta
Breast cancer
p53
Genetically engineered mice
Breast carcinogenesis
Online Access:http://link.springer.com/article/10.1186/s13058-017-0872-z

Internet

http://link.springer.com/article/10.1186/s13058-017-0872-z

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