Structural analysis of missense mutations occurring in the DNA-binding domain of HSF4 associated with congenital cataracts

Structural analysis of missense mutations occurring in the DNA-binding domain of HSF4 associated with congenital cataracts

Congenital cataract (CC) is the major cause of childish blindness, and nearly 50% of CCs are hereditary disorders. HSF4, a member of the heat shock transcription factor family, acts as a key regulator of cell growth and differentiation during the development of sensory organs. Missense mutations in...

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Bibliographic Details
Main Authors: Zaiyu Xiao, Ling Guo, Yang Zhang, Liwei Cui, Yujie Dai, Zhu Lan, Qinghua Zhang, Sheng Wang, Wei Liu
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Structural Biology: X
Subjects:
Congenital cataract
Heat shock factor 4
DNA-binding domain
Molecular dynamics simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152419300133

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http://www.sciencedirect.com/science/article/pii/S2590152419300133

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