TRIM5 alpha drives SIVsmm evolution in rhesus macaques.

TRIM5 alpha drives SIVsmm evolution in rhesus macaques.

The antagonistic interaction with host restriction proteins is a major driver of evolutionary change for viruses. We previously reported that polymorphisms of the TRIM5α B30.2/SPRY domain impacted the level of SIVsmm viremia in rhesus macaques. Viremia in macaques homozygous for the non-restrictive...

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Bibliographic Details
Main Authors: Fan Wu, Andrea Kirmaier, Robert Goeken, Ilnour Ourmanov, Laura Hall, Jennifer S Morgan, Kenta Matsuda, Alicia Buckler-White, Keiko Tomioka, Ronald Plishka, Sonya Whitted, Welkin Johnson, Vanessa M Hirsch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3749954?pdf=render

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http://europepmc.org/articles/PMC3749954?pdf=render

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