Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer
In this study, we synthesized manganese dioxide nanoparticles (MnO2 NPs) stabilized with biocompatible polymers (polyvinylpyrrolidone and polyacrylic acid) and analyzed their effect on non-small cell lung cancer (NSCLC) cells with or without gefitinib resistance in vitro. MnO2 NPs showed glutathione...
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doaj-4e13e921a35a4dceb4ac0a235554fed72020-11-24T22:31:15ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462017-12-01510.3389/fchem.2017.00109320200Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung CancerMi Hyeon Cho0Eun-Seok Choi1Sehee Kim2Sung-Ho Goh3Yongdoo Choi4Biomarker Branch, National Cancer Center, Goyang, South KoreaTherapeutic Target Discovery Branch, National Cancer Center, Goyang, South KoreaBiomarker Branch, National Cancer Center, Goyang, South KoreaTherapeutic Target Discovery Branch, National Cancer Center, Goyang, South KoreaBiomarker Branch, National Cancer Center, Goyang, South KoreaIn this study, we synthesized manganese dioxide nanoparticles (MnO2 NPs) stabilized with biocompatible polymers (polyvinylpyrrolidone and polyacrylic acid) and analyzed their effect on non-small cell lung cancer (NSCLC) cells with or without gefitinib resistance in vitro. MnO2 NPs showed glutathione (GSH)-responsive dissolution and subsequent enhancement in magnetic resonance (MR) imaging. Of note, treatment with MnO2 NPs induced significant cytotoxic effects on NSCLC cells, and additional dose-dependent therapeutic effects were obtained upon X-ray irradiation. Normal cells treated with MnO2 NPs were viable at the tested concentrations. In addition, increased therapeutic efficacy could be achieved when the cells were treated with MnO2 NPs in hypoxic conditions. Therefore, we conclude that the use of MnO2 NPs in MR imaging and combination radiotherapy may be an efficient strategy for the imaging and therapy of NSCLC.http://journal.frontiersin.org/article/10.3389/fchem.2017.00109/fullmanganese dioxide nanoparticlesglutathionelung cancergefitinibradiotherapymagnetic resonance imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mi Hyeon Cho Eun-Seok Choi Sehee Kim Sung-Ho Goh Yongdoo Choi |
spellingShingle |
Mi Hyeon Cho Eun-Seok Choi Sehee Kim Sung-Ho Goh Yongdoo Choi Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer Frontiers in Chemistry manganese dioxide nanoparticles glutathione lung cancer gefitinib radiotherapy magnetic resonance imaging |
author_facet |
Mi Hyeon Cho Eun-Seok Choi Sehee Kim Sung-Ho Goh Yongdoo Choi |
author_sort |
Mi Hyeon Cho |
title |
Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer |
title_short |
Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer |
title_full |
Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer |
title_fullStr |
Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer |
title_full_unstemmed |
Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer |
title_sort |
redox-responsive manganese dioxide nanoparticles for enhanced mr imaging and radiotherapy of lung cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Chemistry |
issn |
2296-2646 |
publishDate |
2017-12-01 |
description |
In this study, we synthesized manganese dioxide nanoparticles (MnO2 NPs) stabilized with biocompatible polymers (polyvinylpyrrolidone and polyacrylic acid) and analyzed their effect on non-small cell lung cancer (NSCLC) cells with or without gefitinib resistance in vitro. MnO2 NPs showed glutathione (GSH)-responsive dissolution and subsequent enhancement in magnetic resonance (MR) imaging. Of note, treatment with MnO2 NPs induced significant cytotoxic effects on NSCLC cells, and additional dose-dependent therapeutic effects were obtained upon X-ray irradiation. Normal cells treated with MnO2 NPs were viable at the tested concentrations. In addition, increased therapeutic efficacy could be achieved when the cells were treated with MnO2 NPs in hypoxic conditions. Therefore, we conclude that the use of MnO2 NPs in MR imaging and combination radiotherapy may be an efficient strategy for the imaging and therapy of NSCLC. |
topic |
manganese dioxide nanoparticles glutathione lung cancer gefitinib radiotherapy magnetic resonance imaging |
url |
http://journal.frontiersin.org/article/10.3389/fchem.2017.00109/full |
work_keys_str_mv |
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