Safety and immunogenicity of a malaria vaccine, Plasmodium falciparum AMA-1/MSP-1 chimeric protein formulated in montanide ISA 720 in healthy adults.

Safety and immunogenicity of a malaria vaccine, Plasmodium falciparum AMA-1/MSP-1 chimeric protein formulated in montanide ISA 720 in healthy adults.

BACKGROUND: The P. falciparum chimeric protein 2.9 (PfCP-2.9) consisting of the sequences of MSP1-19 and AMA-1 (III) is a malaria vaccine candidate that was found to induce inhibitory antibodies in rabbits and monkeys. This was a phase I randomized, single-blind, placebo-controlled, dose-escalation...

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Bibliographic Details
Main Authors: Jinhong Hu, Zhihui Chen, Jun Gu, Mobin Wan, Qian Shen, Marie-Paule Kieny, Jia He, Zhen Li, Qingfeng Zhang, Zarifah Hussain Reed, Yongmei Zhu, Wenjie Li, Yang Cao, Li Qu, Zhifang Cao, Qiang Wang, Haitao Liu, Xuegong Pan, Xiudong Huang, Dongmei Zhang, Xiangyang Xue, Weiqing Pan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2276862?pdf=render

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http://europepmc.org/articles/PMC2276862?pdf=render

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