iNOS Associates With Poor Survival in Melanoma: A Role for Nitric Oxide in the PI3K-AKT Pathway Stimulation and PTEN S-Nitrosylation

iNOS Associates With Poor Survival in Melanoma: A Role for Nitric Oxide in the PI3K-AKT Pathway Stimulation and PTEN S-Nitrosylation

We previously showed that inducible nitric oxide synthase (iNOS) protein expression in melanoma tumor cells is associated with poor patient prognosis. Here, we analyzed the association between iNOS and the oncogenic PI3K-AKT pathway. TCGA data show that iNOS and phospho-Akt Ser473 expression were as...

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Bibliographic Details
Main Authors: Zhen Ding, Dai Ogata, Jason Roszik, Yong Qin, Sun-Hee Kim, Michael T. Tetzlaff, Alexander J. Lazar, Michael A. Davies, Suhendan Ekmekcioglu, Elizabeth A. Grimm
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
melanoma
phosphatase and tensin homolog
nitric oxide
PI3K-AKT axis
S-nitrosylation
inducible nitric oxide synthase
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.631766/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.631766/full

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