Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors

Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors

Histone lysine specific demethylase 1 (LSD1) has become a potential therapeutic target for the treatment of cancer. Discovery and develop novel and potent LSD1 inhibitors is a challenge, although several of them have already entered into clinical trials. Herein, for the first time, we reported the d...

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Bibliographic Details
Main Authors: Liying Ma, Haojie Wang, Yinghua You, Chaoya Ma, Yuejiao Liu, Feifei Yang, Yichao Zheng, Hongmin Liu
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
LSD1 inhibitors
Pyrimidine
Anticancer
Flavin adenine dinucleotide (FAD)
Gastric cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519313693

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http://www.sciencedirect.com/science/article/pii/S2211383519313693

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