Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells

Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells

Anticancer properties of tyrindoleninone and 6-bromoisatin from Dicathais orbita were tested against physiologically normal primary human granulosa cells (HGC) and reproductive cancer cell lines. Tyrindoleninone reduced cancer cell viability with IC50 values of 39 µM (KGN; a tumour-derived granulosa...

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Bibliographic Details
Main Authors: Fiona Young, Kirsten Benkendorff, Vicki Edwards
Format: Article
Language:English
Published: MDPI AG 2012-01-01
Series:Marine Drugs
Subjects:
gynaecological cancers
brominated indoles
marine mollusc
apoptosis
Online Access:http://www.mdpi.com/1660-3397/10/1/64/

Internet

http://www.mdpi.com/1660-3397/10/1/64/

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