Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells

Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells

Anticancer properties of tyrindoleninone and 6-bromoisatin from Dicathais orbita were tested against physiologically normal primary human granulosa cells (HGC) and reproductive cancer cell lines. Tyrindoleninone reduced cancer cell viability with IC50 values of 39 µM (KGN; a tumour-derived granulosa...

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Main Authors: Fiona Young, Kirsten Benkendorff, Vicki Edwards
Format: Article
Language:English
Published: MDPI AG 2012-01-01
Series:Marine Drugs
Subjects:
gynaecological cancers
brominated indoles
marine mollusc
apoptosis
Online Access:http://www.mdpi.com/1660-3397/10/1/64/
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spelling doaj-4e25bf7ab84a423f9741d1c7d25a6fc82020-11-24T23:05:44ZengMDPI AGMarine Drugs1660-33972012-01-01101648310.3390/md10010064Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa CellsFiona YoungKirsten BenkendorffVicki EdwardsAnticancer properties of tyrindoleninone and 6-bromoisatin from Dicathais orbita were tested against physiologically normal primary human granulosa cells (HGC) and reproductive cancer cell lines. Tyrindoleninone reduced cancer cell viability with IC50 values of 39 µM (KGN; a tumour-derived granulosa cell line), 39 μM (JAr), and 156 μM (OVCAR-3), compared to 3516 μM in HGC. Apoptosis in HGC’s occurred after 4 h at 391 µM tyrindoleninone compared to 20 µM in KGN cells. Differences in apoptosis between HGC and KGN cells were confirmed by TUNEL, with 66 and 31% apoptotic nuclei at 4 h in KGN and HGC, respectively. These marine compounds therefore have potential for development as treatments for female reproductive cancers.http://www.mdpi.com/1660-3397/10/1/64/gynaecological cancersbrominated indolesmarine molluscapoptosis
collection DOAJ
language English
format Article
sources DOAJ
author Fiona Young
Kirsten Benkendorff
Vicki Edwards
spellingShingle Fiona Young
Kirsten Benkendorff
Vicki Edwards
Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells
Marine Drugs
gynaecological cancers
brominated indoles
marine mollusc
apoptosis
author_facet Fiona Young
Kirsten Benkendorff
Vicki Edwards
author_sort Fiona Young
title Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells
title_short Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells
title_full Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells
title_fullStr Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells
title_full_unstemmed Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells
title_sort marine compounds selectively induce apoptosis in female reproductive cancer cells but not in primary-derived human reproductive granulosa cells
publisher MDPI AG
series Marine Drugs
issn 1660-3397
publishDate 2012-01-01
description Anticancer properties of tyrindoleninone and 6-bromoisatin from Dicathais orbita were tested against physiologically normal primary human granulosa cells (HGC) and reproductive cancer cell lines. Tyrindoleninone reduced cancer cell viability with IC50 values of 39 µM (KGN; a tumour-derived granulosa cell line), 39 μM (JAr), and 156 μM (OVCAR-3), compared to 3516 μM in HGC. Apoptosis in HGC’s occurred after 4 h at 391 µM tyrindoleninone compared to 20 µM in KGN cells. Differences in apoptosis between HGC and KGN cells were confirmed by TUNEL, with 66 and 31% apoptotic nuclei at 4 h in KGN and HGC, respectively. These marine compounds therefore have potential for development as treatments for female reproductive cancers.
topic gynaecological cancers
brominated indoles
marine mollusc
apoptosis
url http://www.mdpi.com/1660-3397/10/1/64/
work_keys_str_mv AT fionayoung marinecompoundsselectivelyinduceapoptosisinfemalereproductivecancercellsbutnotinprimaryderivedhumanreproductivegranulosacells
AT kirstenbenkendorff marinecompoundsselectivelyinduceapoptosisinfemalereproductivecancercellsbutnotinprimaryderivedhumanreproductivegranulosacells
AT vickiedwards marinecompoundsselectivelyinduceapoptosisinfemalereproductivecancercellsbutnotinprimaryderivedhumanreproductivegranulosacells
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