Ex vivo piperaquine resistance developed rapidly in Plasmodium falciparum isolates in northern Cambodia compared to Thailand

Ex vivo piperaquine resistance developed rapidly in Plasmodium falciparum isolates in northern Cambodia compared to Thailand

Abstract Background The recent dramatic decline in dihydroartemisinin-piperaquine (DHA-PPQ) efficacy in northwestern Cambodia has raised concerns about the rapid spread of piperaquine resistance just as DHA-PPQ is being introduced as first-line therapy in neighbouring countries. Methods Ex vivo para...

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Bibliographic Details
Main Authors: Suwanna Chaorattanakawee, Chanthap Lon, Krisada Jongsakul, Jariyanart Gawee, Somethy Sok, Siratchana Sundrakes, Nareth Kong, Chatchadaporn Thamnurak, Soklyda Chann, Sorayut Chattrakarn, Chantida Praditpol, Nillawan Buathong, Nichapat Uthaimongkol, Philip Smith, Narongrid Sirisopana, Rekol Huy, Satharath Prom, Mark M. Fukuda, Delia Bethell, Douglas S. Walsh, Charlotte Lanteri, David Saunders
Format: Article
Language:English
Published: BMC 2016-10-01
Series:Malaria Journal
Subjects:
Malaria
Drug resistance
Piperaquine
Mefloquine
Cambodia
Thailand
Online Access:http://link.springer.com/article/10.1186/s12936-016-1569-y

Internet

http://link.springer.com/article/10.1186/s12936-016-1569-y

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