The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

Human cells lacking RIF1 are highly sensitive to replication inhibitors, but the reasons for this sensitivity have been enigmatic. Here, we show that RIF1 must be present both during replication stress and in the ensuing recovery period to promote cell survival. Of two isoforms produced by alternati...

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Bibliographic Details
Main Authors: Lotte P Watts, Toyoaki Natsume, Yuichiro Saito, Javier Garzon, Qianqian Dong, Lora Boteva, Nick Gilbert, Masato T Kanemaki, Shin-ichiro Hiraga, Anne D Donaldson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
replication stress
splicing
DNA replication
Online Access:https://elifesciences.org/articles/58020

Internet

https://elifesciences.org/articles/58020

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