Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

Osteoporosis GWAS faces two challenges, causal gene discovery and a lack of phenotypic diversity. Here, the authors use the Diversity Outbred mouse population to inform human GWAS using networks and map genetic loci for 55 bone traits, identifying new potential bone strength genes.

Bibliographic Details
Main Authors: Basel M. Al-Barghouthi, Larry D. Mesner, Gina M. Calabrese, Daniel Brooks, Steven M. Tommasini, Mary L. Bouxsein, Mark C. Horowitz, Clifford J. Rosen, Kevin Nguyen, Samuel Haddox, Emily A. Farber, Suna Onengut-Gumuscu, Daniel Pomp, Charles R. Farber
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23649-0

Internet

https://doi.org/10.1038/s41467-021-23649-0

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