Genetic Deletion of <i>Syndecan-4</i> Alters Body Composition, Metabolic Phenotypes, and the Function of Metabolic Tissues in Female Mice Fed A High-Fat Diet

Genetic Deletion of <i>Syndecan-4</i> Alters Body Composition, Metabolic Phenotypes, and the Function of Metabolic Tissues in Female Mice Fed A High-Fat Diet

Syndecans are transmembrane proteoglycans that, like integrins, bind to components of the extracellular matrix. Previously, we showed significant associations of genetic variants in the <i>Syndecan-4</i> (<i>SDC4</i>) gene with intra-abdominal fat, fasting plasma glucose leve...

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Bibliographic Details
Main Authors: Maria De Luca, Denise Vecchie’, Baskaran Athmanathan, Sreejit Gopalkrishna, Jennifer A. Valcin, Telisha M. Swain, Rogerio Sertie, Kennedy Wekesa, Glenn C. Rowe, Shannon M. Bailey, Prabhakara R. Nagareddy
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Nutrients
Subjects:
heparan sulfate proteoglycans
extracellular matrix
obesity
lipid profile
steatosis
insulin resistance
Online Access:https://www.mdpi.com/2072-6643/11/11/2810

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https://www.mdpi.com/2072-6643/11/11/2810

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