MiR-410 is overexpressed in liver and colorectal tumors and enhances tumor cell growth by silencing FHL1 via a direct/indirect mechanism.

MiR-410 is overexpressed in liver and colorectal tumors and enhances tumor cell growth by silencing FHL1 via a direct/indirect mechanism.

FHL1 is an important tumor-suppressor that is downregulated in multiple tumors by unknown mechanisms. We demonstrated that miR-410 specifically targets the 3'UTR of FHL1. Furthermore, using DNA bisulfite modification and sequencing experiments, we demonstrated that the FHL1 promoter is hypermet...

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Bibliographic Details
Main Authors: Yu Wang, Jie Fu, Mengmeng Jiang, Xiaoai Zhang, Long Cheng, Xiaojie Xu, Zhongyi Fan, Jing Zhang, Qinong Ye, Haifeng Song
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4182719?pdf=render

Internet

http://europepmc.org/articles/PMC4182719?pdf=render

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