Correlative intravital imaging of cGMP signals and vasodilation in mice

Correlative intravital imaging of cGMP signals and vasodilation in mice

Cyclic guanosine monophosphate (cGMP) is an important signaling molecule and drug target in the cardiovascular system. It is well known that stimulation of the vascular nitric oxide (NO)-cGMP pathway results in vasodilation. However, the spatiotemporal dynamics of cGMP signals themselves and the cGM...

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Bibliographic Details
Main Authors: Martin eThunemann, Kjestine eSchmidt, Cor eDe Wit, Xiaoxing eHan, Rakesh K Jain, Dai eFukumura, Robert eFeil
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Physiology
Subjects:
Cardiovascular System
Cyclic GMP
Fluorescence Resonance Energy Transfer
Microcirculation
Nitric Oxide
Vasodilation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00394/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00394/full

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