Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells

Grafting of cells in Parkinson's disease (PD) results in a prion-like infection, exhibiting a Lewy body-like pathology, caused by the recipient cells. The transmission mechanism of Lewy bodies is not completely understood. Therefore, a research idea with a novel experimental strategy is prop...

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Main Author:	Cheng Lin
Format:	Article
Language:	English
Published:	Pensoft Publishers 2018-04-01
Series:	Research Ideas and Outcomes
Subjects:	Parkinson's disease transplantation cell ther
Online Access:	https://riojournal.com/article/25423/

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spelling	doaj-4e33cb58b573461ea852e7c5a301f96a2020-11-25T01:12:43ZengPensoft PublishersResearch Ideas and Outcomes2367-71632018-04-0141410.3897/rio.4.e2542325423Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem CellsCheng Lin0Department of integrated biosciences, Graduate school of frontier sciences, The University of Tokyo Grafting of cells in Parkinson's disease (PD) results in a prion-like infection, exhibiting a Lewy body-like pathology, caused by the recipient cells. The transmission mechanism of Lewy bodies is not completely understood. Therefore, a research idea with a novel experimental strategy is proposed to investigate the transmission mechanism of α-synuclein pathology using PD patient-derived human induced pluripotent stem cells (hiPSC) in an in vitro human cellular and molecular PD model and in vivo mouse PD model for dopaminergic neuron transplantation. https://riojournal.com/article/25423/Parkinson's diseasetransplantationcell ther
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Cheng Lin
spellingShingle	Cheng Lin Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells Research Ideas and Outcomes Parkinson's disease transplantation cell ther
author_facet	Cheng Lin
author_sort	Cheng Lin
title	Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells
title_short	Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells
title_full	Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells
title_fullStr	Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells
title_full_unstemmed	Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells
title_sort	transmission mechanism of lewy body-like α-synucleinopathies in dopaminergic neurons derived from human induced pluripotent stem cells
publisher	Pensoft Publishers
series	Research Ideas and Outcomes
issn	2367-7163
publishDate	2018-04-01
description	Grafting of cells in Parkinson's disease (PD) results in a prion-like infection, exhibiting a Lewy body-like pathology, caused by the recipient cells. The transmission mechanism of Lewy bodies is not completely understood. Therefore, a research idea with a novel experimental strategy is proposed to investigate the transmission mechanism of α-synuclein pathology using PD patient-derived human induced pluripotent stem cells (hiPSC) in an in vitro human cellular and molecular PD model and in vivo mouse PD model for dopaminergic neuron transplantation.
topic	Parkinson's disease transplantation cell ther
url	https://riojournal.com/article/25423/
work_keys_str_mv	AT chenglin transmissionmechanismoflewybodylikeasynucleinopathiesindopaminergicneuronsderivedfromhumaninducedpluripotentstemcells
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Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells

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