Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells
Grafting of cells in Parkinson's disease (PD) results in a prion-like infection, exhibiting a Lewy body-like pathology, caused by the recipient cells. The transmission mechanism of Lewy bodies is not completely understood. Therefore, a research idea with a novel experimental strategy is prop...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
Pensoft Publishers
2018-04-01
|
Series: | Research Ideas and Outcomes |
Subjects: | |
Online Access: | https://riojournal.com/article/25423/ |
id |
doaj-4e33cb58b573461ea852e7c5a301f96a |
---|---|
record_format |
Article |
spelling |
doaj-4e33cb58b573461ea852e7c5a301f96a2020-11-25T01:12:43ZengPensoft PublishersResearch Ideas and Outcomes2367-71632018-04-0141410.3897/rio.4.e2542325423Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem CellsCheng Lin0Department of integrated biosciences, Graduate school of frontier sciences, The University of Tokyo Grafting of cells in Parkinson's disease (PD) results in a prion-like infection, exhibiting a Lewy body-like pathology, caused by the recipient cells. The transmission mechanism of Lewy bodies is not completely understood. Therefore, a research idea with a novel experimental strategy is proposed to investigate the transmission mechanism of α-synuclein pathology using PD patient-derived human induced pluripotent stem cells (hiPSC) in an in vitro human cellular and molecular PD model and in vivo mouse PD model for dopaminergic neuron transplantation. https://riojournal.com/article/25423/Parkinson's diseasetransplantationcell ther |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheng Lin |
spellingShingle |
Cheng Lin Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells Research Ideas and Outcomes Parkinson's disease transplantation cell ther |
author_facet |
Cheng Lin |
author_sort |
Cheng Lin |
title |
Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells |
title_short |
Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells |
title_full |
Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells |
title_fullStr |
Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells |
title_full_unstemmed |
Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells |
title_sort |
transmission mechanism of lewy body-like α-synucleinopathies in dopaminergic neurons derived from human induced pluripotent stem cells |
publisher |
Pensoft Publishers |
series |
Research Ideas and Outcomes |
issn |
2367-7163 |
publishDate |
2018-04-01 |
description |
Grafting of cells in Parkinson's disease (PD) results in a prion-like infection, exhibiting a Lewy body-like pathology, caused by the recipient cells. The transmission mechanism of Lewy bodies is not completely understood. Therefore, a research idea with a novel experimental strategy is proposed to investigate the transmission mechanism of α-synuclein pathology using PD patient-derived human induced pluripotent stem cells (hiPSC) in an in vitro human cellular and molecular PD model and in vivo mouse PD model for dopaminergic neuron transplantation.
|
topic |
Parkinson's disease transplantation cell ther |
url |
https://riojournal.com/article/25423/ |
work_keys_str_mv |
AT chenglin transmissionmechanismoflewybodylikeasynucleinopathiesindopaminergicneuronsderivedfromhumaninducedpluripotentstemcells |
_version_ |
1725165416821555200 |