The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.
Recently, it was demonstrated that pancreatic new-born glucagon-producing cells can regenerate and convert into insulin-producing β-like cells through the ectopic expression of a single gene, Pax4. Here, combining conditional loss-of-function and lineage tracing approaches, we show that the selectiv...
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-10-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC3814322?pdf=render |