An Inflammatory Nucleus Pulposus Tissue Culture Model to Test Molecular Regenerative Therapies: Validation with Epigallocatechin 3-Gallate

An Inflammatory Nucleus Pulposus Tissue Culture Model to Test Molecular Regenerative Therapies: Validation with Epigallocatechin 3-Gallate

Organ cultures are practical tools to investigate regenerative strategies for the intervertebral disc. However, most existing organ culture systems induce severe tissue degradation with only limited representation of the in vivo processes. The objective of this study was to develop a space- and cost...

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Bibliographic Details
Main Authors: Olga Krupkova, Marian Hlavna, Julie Amir Tahmasseb, Joel Zvick, Dominik Kunz, Keita Ito, Stephen J. Ferguson, Karin Wuertz-Kozak
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:International Journal of Molecular Sciences
Subjects:
nucleus pulposus
organ culture model
degenerative disc disease
IL-1β
TNF-α
chondroitinase ABC
epigallocatechin 3-gallate
inflammation
extracellular matrix
Online Access:http://www.mdpi.com/1422-0067/17/10/1640

Internet

http://www.mdpi.com/1422-0067/17/10/1640

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