Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy.

Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy.

BACKGROUND: Uremic cardiomyopathy contributes substantially to mortality in chronic kidney disease (CKD) patients. Glucagon-like peptide-1 (GLP-1) may improve cardiac function, but is mainly degraded by dipeptidyl peptidase-4 (DPP-4). METHODOLOGY/PRINCIPAL FINDINGS: In a rat model of chronic renal f...

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Bibliographic Details
Main Authors: Lyubov Chaykovska, Karoline von Websky, Jan Rahnenführer, Markus Alter, Susi Heiden, Holger Fuchs, Frank Runge, Thomas Klein, Berthold Hocher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3220703?pdf=render

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http://europepmc.org/articles/PMC3220703?pdf=render

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