Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-D-aspartate currents by dopamine D1 receptor activation in striatum

Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-D-aspartate currents by dopamine D1 receptor activation in striatum

Dopamine, via activation of D1 receptors, enhances N-methyl-D-aspartate (NMDA) receptor-mediated responses in striatal medium-sized spiny neurons. However, the role of specific NMDA receptor subunits in this enhancement remains unknown. Here we used genetic and pharmacological tools to dissect the c...

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Bibliographic Details
Main Authors: Emily L Jocoy, Véronique M André, Damian M Cummings, Shilpa P Rao, Nanping eWu, Amy J Ramsey, Marc G Caron, Carlos eCepeda, Michael S Levine
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-05-01
Series:Frontiers in Systems Neuroscience
Subjects:
Dopamine
NMDA
Striatum
modulation
receptor subunits
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsys.2011.00028/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnsys.2011.00028/full

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