Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders
Placenta accreta spectrum (PAS) is a high-risk obstetrical complication associated with significant morbidity and mortality. Here the authors discover a uniquely high prevalence of circulating trophoblasts clusters in PAS and explore their diagnostic potential to augment current diagnostic modalitie...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24627-2 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yalda Afshar Jiantong Dong Pan Zhao Lei Li Shan Wang Ryan Y. Zhang Ceng Zhang Ophelia Yin Christina S. Han Brett D. Einerson Tania L. Gonzalez Huirong Zhang Anqi Zhou Zhuo Yang Shih-Jie Chou Na Sun Ju Cheng Henan Zhu Jing Wang Tiffany X. Zhang Yi-Te Lee Jasmine J. Wang Pai-Chi Teng Peng Yang Dongping Qi Meiping Zhao Myung-Shin Sim Ruilian Zhe Jeffrey D. Goldstein John Williams Xietong Wang Qingying Zhang Lawrence D. Platt Chang Zou Margareta D. Pisarska Hsian-Rong Tseng Yazhen Zhu |
| spellingShingle |
Yalda Afshar Jiantong Dong Pan Zhao Lei Li Shan Wang Ryan Y. Zhang Ceng Zhang Ophelia Yin Christina S. Han Brett D. Einerson Tania L. Gonzalez Huirong Zhang Anqi Zhou Zhuo Yang Shih-Jie Chou Na Sun Ju Cheng Henan Zhu Jing Wang Tiffany X. Zhang Yi-Te Lee Jasmine J. Wang Pai-Chi Teng Peng Yang Dongping Qi Meiping Zhao Myung-Shin Sim Ruilian Zhe Jeffrey D. Goldstein John Williams Xietong Wang Qingying Zhang Lawrence D. Platt Chang Zou Margareta D. Pisarska Hsian-Rong Tseng Yazhen Zhu Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders Nature Communications |
| author_facet |
Yalda Afshar Jiantong Dong Pan Zhao Lei Li Shan Wang Ryan Y. Zhang Ceng Zhang Ophelia Yin Christina S. Han Brett D. Einerson Tania L. Gonzalez Huirong Zhang Anqi Zhou Zhuo Yang Shih-Jie Chou Na Sun Ju Cheng Henan Zhu Jing Wang Tiffany X. Zhang Yi-Te Lee Jasmine J. Wang Pai-Chi Teng Peng Yang Dongping Qi Meiping Zhao Myung-Shin Sim Ruilian Zhe Jeffrey D. Goldstein John Williams Xietong Wang Qingying Zhang Lawrence D. Platt Chang Zou Margareta D. Pisarska Hsian-Rong Tseng Yazhen Zhu |
| author_sort |
Yalda Afshar |
| title |
Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders |
| title_short |
Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders |
| title_full |
Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders |
| title_fullStr |
Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders |
| title_full_unstemmed |
Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders |
| title_sort |
circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-08-01 |
| description |
Placenta accreta spectrum (PAS) is a high-risk obstetrical complication associated with significant morbidity and mortality. Here the authors discover a uniquely high prevalence of circulating trophoblasts clusters in PAS and explore their diagnostic potential to augment current diagnostic modalities for the early detection of PAS. |
| url |
https://doi.org/10.1038/s41467-021-24627-2 |
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doaj-4e49a8dab8414c93b2b35b20d3a326502021-08-08T11:37:08ZengNature Publishing GroupNature Communications2041-17232021-08-0112111410.1038/s41467-021-24627-2Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disordersYalda Afshar0Jiantong Dong1Pan Zhao2Lei Li3Shan Wang4Ryan Y. Zhang5Ceng Zhang6Ophelia Yin7Christina S. Han8Brett D. Einerson9Tania L. Gonzalez10Huirong Zhang11Anqi Zhou12Zhuo Yang13Shih-Jie Chou14Na Sun15Ju Cheng16Henan Zhu17Jing Wang18Tiffany X. Zhang19Yi-Te Lee20Jasmine J. Wang21Pai-Chi Teng22Peng Yang23Dongping Qi24Meiping Zhao25Myung-Shin Sim26Ruilian Zhe27Jeffrey D. Goldstein28John Williams29Xietong Wang30Qingying Zhang31Lawrence D. Platt32Chang Zou33Margareta D. Pisarska34Hsian-Rong Tseng35Yazhen Zhu36Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesClinical Medical Research Center, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s HospitalCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los AngelesDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los AngelesDivision of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, University of Utah HealthDepartment of Obstetrics and Gynecology, Cedars-Sinai Medical CenterClinical Medical Research Center, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s HospitalCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical CenterSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical CenterCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesBeijing National Laboratory for Molecular Sciences, MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry and Molecular Engineering, Peking UniversityDepartments of Computational Medicine & Medicine, David Geffen School of Medicine, University of California, Los AngelesClinical Medical Research Center, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s HospitalDepartment of Pathology and Laboratory Medicine, Ronald Reagan Medical Center, David Geffen School of Medicine, University of California, Los AngelesDepartment of Obstetrics and Gynecology, Cedars-Sinai Medical CenterDepartment of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong UniversityCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los AngelesClinical Medical Research Center, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s HospitalDepartment of Obstetrics and Gynecology, Cedars-Sinai Medical CenterCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesCalifornia NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los AngelesPlacenta accreta spectrum (PAS) is a high-risk obstetrical complication associated with significant morbidity and mortality. Here the authors discover a uniquely high prevalence of circulating trophoblasts clusters in PAS and explore their diagnostic potential to augment current diagnostic modalities for the early detection of PAS.https://doi.org/10.1038/s41467-021-24627-2 |