Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson’s Disease

Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson’s Disease

According to emerging studies, the excessive activation of microglia and the subsequent release of pro-inflammatory cytokines play important roles in the pathogenesis and progression of Parkinson’s disease (PD). However, the exact mechanisms governing chronic neuroinflammation remain elusive. Findin...

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Bibliographic Details
Main Authors: Yunna Li, Yun Xia, Sijia Yin, Fang Wan, Junjie Hu, Liang Kou, Yadi Sun, Jiawei Wu, Qiulu Zhou, Jinsha Huang, Nian Xiong, Tao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
Parkinson’s disease
microglia
NLRP3 inflammasome
α-synuclein
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.719807/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.719807/full

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