High-Resolution Respirometry Reveals MPP<sup>+</sup> Mitochondrial Toxicity Mechanism in a Cellular Model of Parkinson’s Disease

High-Resolution Respirometry Reveals MPP<sup>+</sup> Mitochondrial Toxicity Mechanism in a Cellular Model of Parkinson’s Disease

MPP<sup>+</sup> is the active metabolite of MPTP, a molecule structurally similar to the herbicide Paraquat, known to injure the dopaminergic neurons of the nigrostriatal system in Parkinson’s disease models. Within the cells, MPP<sup>+</sup> accumulates in mitochondria where...

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Bibliographic Details
Main Authors: Pierpaolo Risiglione, Loredana Leggio, Salvatore A. M. Cubisino, Simona Reina, Greta Paternò, Bianca Marchetti, Andrea Magrì, Nunzio Iraci, Angela Messina
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
MPP<sup>+</sup>
mitochondria
Parkinson’s disease
high-resolution respirometry
SH-SY5Y cells
Online Access:https://www.mdpi.com/1422-0067/21/21/7809

Internet

https://www.mdpi.com/1422-0067/21/21/7809

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