Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site

Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site

Abstract Background The binding of HIV-1 Envelope glycoproteins (Env) to host receptor CD4 exposes vulnerable conserved epitopes within the co-receptor binding site (CoRBS) which are required for the engagement of either CCR5 or CXCR4 co-receptor to allow HIV-1 entry. Antibodies against this region...

Full description

Bibliographic Details
Main Authors: William D. Tolbert, Rebekah Sherburn, Neelakshi Gohain, Shilei Ding, Robin Flinko, Chiara Orlandi, Krishanu Ray, Andrés Finzi, George K. Lewis, Marzena Pazgier
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Biology
Subjects:
HIV-1
Env
Co-receptor binding site
ADCC
N12-i2
Online Access:http://link.springer.com/article/10.1186/s12915-020-00819-y

Internet

http://link.springer.com/article/10.1186/s12915-020-00819-y

Similar Items