IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R

IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R

Abstract Metastasis is the major reason for the high mortality of colorectal cancer (CRC) patients and its molecular mechanism remains unclear. Here, we report a novel role of Homeobox A13 (HOXA13), a member of the Homeobox (HOX) family, in promoting CRC metastasis. The elevated expression of HOXA13...

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Bibliographic Details
Main Authors: Chenyang Qiao, Wenjie Huang, Jie Chen, Weibo Feng, Tongyue Zhang, Yijun Wang, Danfei Liu, Xiaoyu Ji, Meng Xie, Mengyu Sun, Daiming Fan, Kaichun Wu, Limin Xia
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03833-2

Internet

https://doi.org/10.1038/s41419-021-03833-2

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