Basic evidence for class A G-protein-coupled receptor heteromerization
Cell membrane receptors rarely work on isolation, often they form oligomeric complexes with other receptor molecules and they may directly interact with different proteins of the signal transduction machinery. For a variety of reasons, rhodopsin-like class A G-protein-coupled receptors (GPCRs) seem...
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doaj-4e5d1aa623dc4603aa9a3dee43ed282e2020-11-24T23:40:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122016-03-01710.3389/fphar.2016.00076181687Basic evidence for class A G-protein-coupled receptor heteromerizationRafael eFranco0Rafael eFranco1Eva eMartínez-Pinilla2Eva eMartínez-Pinilla3Jose L Lanciego4Jose L Lanciego5Gema eNavarro6Gema eNavarro7University of BarcelonaCIBERNEDCIMAInstituto de Neurociencias del Principado de AsturiasCIMACIBERNEDUniversity of BarcelonaCIBERNEDCell membrane receptors rarely work on isolation, often they form oligomeric complexes with other receptor molecules and they may directly interact with different proteins of the signal transduction machinery. For a variety of reasons, rhodopsin-like class A G-protein-coupled receptors (GPCRs) seem an exception to the general rule of receptor-receptor direct interaction. In fact, controversy surrounds their potential to form homo- hetero-dimers/oligomers with other class A GPCRs; in a sense, the field is going backwards instead of forward. This review focuses on the convergent, complementary and telling evidence showing that homo- and heteromers of class A GPCRs exist in transfected cells and, more importantly, in natural sources. It is time to decide between questioning the occurrence of heteromers or, alternatively, facing the vast scientific and technical challenges that class A receptor-dimer/oligomer existence pose to Pharmacology and to Drug Discovery.http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00076/fulldimerDopamine receptordimerizationdopamine receptorsGPCRheterodimer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rafael eFranco Rafael eFranco Eva eMartínez-Pinilla Eva eMartínez-Pinilla Jose L Lanciego Jose L Lanciego Gema eNavarro Gema eNavarro |
spellingShingle |
Rafael eFranco Rafael eFranco Eva eMartínez-Pinilla Eva eMartínez-Pinilla Jose L Lanciego Jose L Lanciego Gema eNavarro Gema eNavarro Basic evidence for class A G-protein-coupled receptor heteromerization Frontiers in Pharmacology dimer Dopamine receptor dimerization dopamine receptors GPCR heterodimer |
author_facet |
Rafael eFranco Rafael eFranco Eva eMartínez-Pinilla Eva eMartínez-Pinilla Jose L Lanciego Jose L Lanciego Gema eNavarro Gema eNavarro |
author_sort |
Rafael eFranco |
title |
Basic evidence for class A G-protein-coupled receptor heteromerization |
title_short |
Basic evidence for class A G-protein-coupled receptor heteromerization |
title_full |
Basic evidence for class A G-protein-coupled receptor heteromerization |
title_fullStr |
Basic evidence for class A G-protein-coupled receptor heteromerization |
title_full_unstemmed |
Basic evidence for class A G-protein-coupled receptor heteromerization |
title_sort |
basic evidence for class a g-protein-coupled receptor heteromerization |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2016-03-01 |
description |
Cell membrane receptors rarely work on isolation, often they form oligomeric complexes with other receptor molecules and they may directly interact with different proteins of the signal transduction machinery. For a variety of reasons, rhodopsin-like class A G-protein-coupled receptors (GPCRs) seem an exception to the general rule of receptor-receptor direct interaction. In fact, controversy surrounds their potential to form homo- hetero-dimers/oligomers with other class A GPCRs; in a sense, the field is going backwards instead of forward. This review focuses on the convergent, complementary and telling evidence showing that homo- and heteromers of class A GPCRs exist in transfected cells and, more importantly, in natural sources. It is time to decide between questioning the occurrence of heteromers or, alternatively, facing the vast scientific and technical challenges that class A receptor-dimer/oligomer existence pose to Pharmacology and to Drug Discovery. |
topic |
dimer Dopamine receptor dimerization dopamine receptors GPCR heterodimer |
url |
http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00076/full |
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