Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis.

BACKGROUND: Mutations in the coding region of angiogenin (ANG) gene have been found in patients suffering from Amyotrophic Lateral Sclerosis (ALS). Neurodegeneration results from the loss of angiogenic ability of ANG (protein coded by ANG). In this work, we performed extensive molecular dynamics (MD...

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Bibliographic Details
Main Authors: Aditya K Padhi, Hirdesh Kumar, Suhas V Vasaikar, Bhyravabhotla Jayaram, James Gomes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3288110?pdf=render