Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

Abstract Background A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues. We investigated aggrecan proteolysis patterns in cartilage expl...

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Bibliographic Details
Main Authors: Per Swärd, Yang Wang, Maria Hansson, L. Stefan Lohmander, Alan J. Grodzinsky, André Struglics
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Arthritis Research & Therapy
Subjects:
Aggrecan
Cartilage injury
Fibrous joint capsule
Knee injury
Synovium
Metalloproteinases
Online Access:http://link.springer.com/article/10.1186/s13075-017-1318-9

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http://link.springer.com/article/10.1186/s13075-017-1318-9

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