Structural Changes of Sodium Warfarin in Tablets Affecting the Dissolution Profiles and Potential Safety of Generic Substitution

Structural Changes of Sodium Warfarin in Tablets Affecting the Dissolution Profiles and Potential Safety of Generic Substitution

At present, the risk of generic substitutions in warfarin tablets is still being discussed. The aim of this study was to assess whether API interactions with commonly used excipients may affect the safety of generic replacement of warfarin sodium tablets. These interactions were observed during an a...

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Bibliographic Details
Main Authors: Jan Muselík, Martina Urbanova, Eva Bartoníčková, Jakub Palovčík, David Vetchý, Jiří Czernek, Larisa Janisova, Nadiia Velychkivska, Aleš Franc, Jiří Brus
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
warfarin
solid-state NMR
polymorphism
stability
particle size
bioavailability
Online Access:https://www.mdpi.com/1999-4923/13/9/1364

Internet

https://www.mdpi.com/1999-4923/13/9/1364

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