Synthesis of New Water Soluble β-Cyclodextrin@Curcumin Conjugates and In Vitro Safety Evaluation in Primary Cultures of Rat Cortical Neurons

Synthesis of New Water Soluble β-Cyclodextrin@Curcumin Conjugates and In Vitro Safety Evaluation in Primary Cultures of Rat Cortical Neurons

Self-aggregation of Curcumin (Cur) in aqueous biological environment decreases its bioavailability and in vivo therapeutic efficacy, which hampers its clinical use as candidate for reducing risk of neurodegenerative diseases. Here, we focused on the design of new Cur- β-Cyclodextrin nanoconjugates t...

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Bibliographic Details
Main Authors: Amina Ben Mihoub, Samir Acherar, Céline Frochot, Catherine Malaplate, Frances T. Yen, Elmira Arab-Tehrany
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
curcumin
β-cyclodextrin
click chemistry
nanoconjugates
neurodegenerative prevention
Online Access:https://www.mdpi.com/1422-0067/22/6/3255

Internet

https://www.mdpi.com/1422-0067/22/6/3255

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