Lynch syndrome-associated endometrial carcinoma with MLH1 germline mutation and MLH1 promoter hypermethylation: a case report and literature review

Lynch syndrome-associated endometrial carcinoma with MLH1 germline mutation and MLH1 promoter hypermethylation: a case report and literature review

Abstract Background Lynch syndrome is an autosomal dominant inherited disease caused by germline mutations in mismatch repair genes. Analysis for microsatellite instability (MSI) and immunohistochemistry (IHC) of protein expressions of disease-associated genes is used to screen for Lynch syndrome in...

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Main Authors: Takanori Yokoyama, Kazuhiro Takehara, Nao Sugimoto, Keika Kaneko, Etsuko Fujimoto, Mika Okazawa-Sakai, Shinichi Okame, Yuko Shiroyama, Takashi Yokoyama, Norihiro Teramoto, Shozo Ohsumi, Shinya Saito, Kazuho Imai, Kokichi Sugano
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Cancer
Subjects:
Lynch syndrome
Endometrial cancer
MLH1 promoter hypermethylation
MLH1 germline mutation
Screening
Online Access:http://link.springer.com/article/10.1186/s12885-018-4489-0

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http://link.springer.com/article/10.1186/s12885-018-4489-0

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